Nicolas Rosewick
About
Experiences
Skills
Teaching
Publications
Contact
Hi, I'm Nicolas Rosewick
I'm a belgian bioinformatician passionate about biological data analysis, 'omics and other cool stuffs.
Experiences
08/2019-current
Senior Bioinformatician
Erasme Hospital - Cliniques Universitaires de Bruxelles
Université Libre de Bruxelles
- In charge of bioinformatics analysis in the Laboratory of Experimental Gastroenterology
- Focus on Next-Generation sequencing analysis (Whole Genome sequencing, RNA-Seq, single-cell sequencing, ...) in the context of Gastrointestinal diseases (HCC, IBD, NASH, ...)
04/2018-08/2019
Project Leader Bioinformatics - Genomics
Sciensano - National Public Health Institute of Belgium
- In charge of Next Generation Sequencing and genomics projects within Sciensano and Healthdata.be
- Developement and management of infrastructure for genomics data storage and bioinformatics data analysis.
- Management of Belgium-wide projects focused on NGS and genomics in the context of public health
01/2018-04/2018
Bioinformatican in Translational Research
European Organisation for Research and Treatment of Cancer (EORTC)
- Head of Bioinformatics data analysis within EORTC Translational Research Unit.
- Development of genomic and transcriptomic pipelines for multiple European clinical studies related to cancer.
- Creation and management of a clinical and genomic database centralizing data for European clinical studies.
2015-01/2018
Bioinformatican - PostDoctoral Researcher - F.R.S.-FNRS Télévie
Laboratory of experimental hematology, Jules Bordet Institute, ULB, Belgium
Unit of Animal Genomics (Prof. M. Georges), GIGA, University of Liège
- Genomic (DNA-Seq) and transcriptomic (RNA-Seq) approaches to study tumor evolution and intra-tumor heterogeneity in virus-induced leukemias (HTLV-1)
- Design of multiple analysis workflows (R, perl, bash,...) regarding ‘omics data.
2010-2015
Ph.D. in Biomedial Sciences – Bioinformatics
Laboratory of experimental hematology, Jules Bordet Institute, ULB, Belgium
Unit of Animal Genomics (Prof. M. Georges), GIGA, University of Liège
- Transcriptomic landscape of a virus induced leukemia (HTLV-1). Bioinformatic analysis of DNA-Seq, RNA-Seq, smallRNA-Seq, ChiP-Seq, ...
- Bioinformatic workflow to identify virus-host chimeric transcripts
2007-2010
Master in Bioinformatics and Modelling - Genomics, Proteomics and Evolution
Faculty of Sciences, Université Libre de Bruxelles (ULB), Belgium
Technical
Skills
#Bioinformatics
High-Throughput sequencing ('Omics) data analysis
RNA-Seq : gene expression, fusion gene, alternative splicing, ...
DNA-Seq : Structural variant and SNP calling, ...
smallRNA-Seq, ChIP-Seq, ...
Various sequencing plateforms : Illumina, PacBio, Oxford Nanopore
Single-cell genomics
Epigenomics : Illumina 450K Infinium Methylation BeadChip array
microArray data analysis (limma,…) and qRT-PCR (Taqman LDA)
Various sequence alignment tools (bwa, bowtie, STAR, Blast, Blat, Clustal, GMAP,...)
Biological databases: ENSEMBL, UCSC, GDC-TCGA, COSMIC, Kegg, ...
#Statistics
Machine learning applied to high-dimensional/large-scale biological data
Supervised and unsupervised clustering and classification
Regression analysis : linear regression, GLM, cross-validation
Uni- and multi-variate analysis
Very good proficiency in R (Tidyverse, Bioconductor)
Teaching
2016 and 2017 workshop organizer/lecturer: – Introduction to High-Throughput Sequencing (RNA-Seq), part of the Belgian Doctoral School in Cancerology
Publications
Monitoring molecular response in adult t-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality
, M. Artesi*, A. Marcais*, K. Durkin,
N. Rosewick
, V. Hahaut, F. Suarez, A. Trinquand, L. Lhermitte, V. Asnafi, A V. Fenoel, A. Burny, M. Georges, O. Hermine, A. Van den Broeke , Leukemia, doi: 10.1038/leu.2017.260, August 2017.
HTLV-1-Induced Leukotriene B4 Secretion by T Cells Promotes T Cell Recruitment and Virus Propagation
, F. Percher*, C. Curis*, E. Pérès*, M. Artesi,
N. Rosewick
, P. Jeannin, A. Gessain, O. Gout, R. Mahieux, P-E. Ceccaldi,A. Van den Broeke, M. Duc Dodon, P V. Afonso, Nature Communications, doi:10.1038/ncomms15890, June 2017.
Cis-perturbation of cancer drivers by the HTLV-1/BLV proviruses is a major early determinant of leukemogenesis
,
N. Rosewick
*, K. Durkin*, M. Artesi*, A. Marçais, V. Hahaut, P. Griebel, N. Arsic, V. Avettand-Fenoel, A. Burny, C. Charlier, O. Hermine, M. Georges, A. Van den Broeke,. Nature Communications, 8, 15264 doi : 10,1038/ncomms15264, May 2017.
Characterization of novel Bovine Leukemia Virus (BLV) antisense transcripts by deep sequencing reveals constitutive expression in tumors and transcriptional interaction with viral microRNAs
,K. Durkin,
N. Rosewick
,M. Artesi, V. Hahaut, P. Griebel, N. Arsic, A. Burny, M. Georges, A. Van den Broeke, Retrovirology, vol. 13, no 1, p. 1. doi:10.1186/s12977-016-0267-8, May 2016
Deep sequencing reveals abundant noncanonical retroviral microRNAs in B-cell leukemia/lymphoma
,
N. Rosewick
, M. Momont, K. Durkin, H. Takeda, F. Caiment, Y. Cleuter, C. Vernin, F. Mortreux, E Wattel, A. Burny, M. Georges, A. Van den Broeke , PNAS (Proc. Natl. Acad. Sci. U.S.A.), vol.110, no. 6, pp. 2306-2311, doi: 10.1073/pnas.1213842110, Feb 2013.
Contact
nicolas.rosewick@gmail.com
+32 (0) 494 82 97 71
linkedin.com/in/nrosewick
@nrosewick
Nicolas Rosewick